Tumor lysis syndrome is a metabolic emergency caracterizad by electrolyte alteration with or. Started in 1995, this collection now contains 6760 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Inquiries should be made with regard to the following. Supported in part by grants ca21765 and u01 gm92666 from the. The tumor lysis syndrome is the most common diseaserelated emergency in children and adults with hematologic cancers.
Tumoral ysis syndrome and acute renal insufficiency. Guidelines for the management of pediatric and adult tumor lysis syndrome. The pediatric population is especially at risk of tumor lysis syndrome because it has a high rate of fastgrowing tumors, such as those of hematologic. The pediatric population is especially at risk of tumor lysis syndrome because it has a high rate of fastgrowing tumors, such as those of. Tumor lysis syndrome is an oncometabolic emergency resulting from rapid cell death. The pediatric population is especially at risk of tumor lysis syndrome because it has a high rate of fastgrowing tumors, such as those of hematologic origin. Tumor lysis syndrome sometimes happens after cancer treatment destroys tumors. Summary a right management of the tumor lysis syn drome is essential for the ongoing improvement in survival and treatment of patients with hematological malignancies. Proper recognition of the risk factors that can cause this syndrome, as well as specific prevention and treatment has substantially decreased complications and improved survival in these patients. Clinicians should stratify every hospitalized cancer patient and especially those receiving chemotherapy for the risk of tumor lysis syndrome. In tumor lysis syndrome, a constellation of clinical signs and symptoms may develop prior to the initiation of chemotherapy or, more commonly, within 72 hours after administration of cytotoxic therapy. Abstract tumoral lysis syndrome in pediatrics tumor lysis syndrome is a metabolic emergency resulting from the rapid and massive destruction of tumor. Tumour lysis syndrome tls is a lifethreatening emergency characterised by a massive cytolysis with the release of intracellular electrolytes, nucleic acids, and metabolites into the circulation.1037 663 1294 460 514 730 1471 510 401 1501 537 999 785 1284 1286 1421 830 1481 370 1421 17 1040 559 842 1639 949 501 526 1373 910 322 755 589 769 1177 653 1113 810 1494 899 240 1386 526 975 1224 424 532 644